Search results for "C [POLY I]"
showing 10 items of 30703 documents
Spherically symmetric inhomogeneous cosmological models
2014
Protein levels of brain-derived neurotrophic factor in the hippocampus of low/high aerobic capacity rats
2010
Hippocrates and Plato have first documented the connection between a healthy mind and body, during a period which launched analytical thinking and philosophy in Ancient Greece. Modern research has also indicated the contribution of an active lifestyle to enhanced brain performance and decreased incidence of neurodegenerative diseases and mood disorders such as Alzheimer’s disease and depression respectively. This has been hypothesized to emerge through mechanisms which are enhanced by exercise and contribute on brain plas-ticity and health. The Neurotrophins hypothesis implicates several molecules in brain plasticity and healthy aging. Among them, Brain-derived Neurotrophic Factor (BDNF) ha…
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety
2019
σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…
Trzy poziomy struktur i kompozycja w wyroczniach przeciw Egiptowi Księga Ezechiela rozdziały 29–32 w świetle retoryki hebrajskiej
2022
Kontekstem badań było to, że różni komentatorzy Księgi Ezechiela proponują różniące się między sobą struktury badanych tekstów. Większość z nich pracowała (nadal pracuje) metodami diachronicznymi. Zazwyczaj ci autorzy układają wersy w grupy i tym grupom nadają tytuły. Dlatego celem badań stało się odkrycie struktur opartych o wersy tekstu biblijnego. Można wtedy wskazać konkretne wersy (lub ich części, człony), których użył starożytny autor natchniony. Dlatego zastosowano metodę biblijnej retoryki hebrajskiej, która ma 3 etapy: analizę oddolną, analizę odgórną oraz interpretację teologiczną. W wyniku przeprowadzonych badań na pierwszych dwóch etapach odkryto, że teksty wyroczni przeciw Egip…
Crowdsourcing as a mode of open innovation: Exploring drivers of success of a multisided platform through system dynamics modelling
2020
This article aims to explore drivers of success of a crowdsourcing platform. The study conceptualizes crowdsourcing as a mode of open innovation and places such a concept within the context of the sharing economy. Upon this framework, the paper analyses the case of InnoCentive, a successful crowdsourcing platform where innovation-driven organizations search for solutions to their R&D tasks. The system dynamics model frames main InnoCentive business processes and offers a causal perspective on the relationships between platform performance—in terms of users base—and resources structure. The discussion on simulation outputs is carried out through a dynamic performance management view of p…
Addressing Patients Mobility through a Dynamic Performance Management perspective: the case of Sicily
Al giorno d'oggi molte regioni italiane sperimentano il fenomeno della mobilità sanitaria passiva, consistente nella tendenza dei loro residenti a rivolgersi ad altri sistemi sanitari regionali, spesso caratterizzati da miglior reputazione, per ricevere assistenza sanitaria. Poiché il Servizio Sanitario Italiano (SSN) è pubblico e regionalizzato, ogni governo regionale ha la responsabilità di prestare assistenza sanitaria ai propri residenti, garantendo al contempo ad ogni cittadino la libertà di essere curato fuori dalla propria giurisdizione, e compensando le regioni di destinazione per i servizi sanitari resi ai non residenti. Nonostante tale diritto di scelta sia un punto di forza del S…
A dynamic performance management approach to support local strategic planning
2015
In spite of efforts devoted in the last decades to local strategic planning, such field of research and practice has been frequently characterized by a lack of implementation. We argue here that this phenomenon is due to the limitations of the static and linear approach to local strategic planning in fostering the development of common shared view among policy makers on the relevant system's structure and behavior. By means of a case-study, we illustrate how an approach based on system dynamics modeling applied to Performance Management can be useful to overcome such weaknesses. The proposed approach enhances a better understanding of the causes and effects related to adopted policies, unde…
Assessing the Reduction Strategies of the Italian Measles Outbreaks through Dynamic Performance Management (DPM) approach
Lack of Good Governance or hazard of consumers e-Health? Evidence through a dynamic outcome based-performance in the Italian healthcare sector about …
This research aims to analyse the management of the health policies to contain the measles outbreaks in Italy. In particular, this study wants to find out what are the key factors that led to the measles outbreak of 2017 and its previous cyclical trend, analysing the impact of ehealth strategy in the management of the epidemics. Understanding the complexity of this issue will help to evaluate the actual policies of the Italian Ministry of Healthcare and to steer the policy-makers to frame sustainable policies to manage the risk of a measles outbreak. The thesis is structured in four chapters. The first chapter, through a literature review, discusses the evolution of the management of epidem…
'REOFUT' as an Observation Tool for Tactical Analysis on Offensive Performance in Soccer: Mixed Method Perspective
2019
Performance analysis in complex sports like soccer requires the study of the influence of the interaction between both teams during the game on final performance. The mixed methods approach involves the collection, analysis, and interpretation of qualitative and quantitative data for the same purpose and within the framework of the same study. To build certain observation tools, mixed methods are necessary in order to take advantage of integration between qualitative and quantitative elements. The aim of this study was to develop a new no standard observation tool to analyze soccer offensive performance considering not only the observed team but also some aspects of the opponent behavior, a…